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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
26.36
Human Site:
T194
Identified Species:
36.25
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
T194
R
T
A
C
R
D
N
T
S
V
Y
H
I
S
G
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
T194
R
T
A
Y
R
D
N
T
S
V
Y
H
I
S
G
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
T193
R
T
A
Y
R
D
N
T
S
V
Y
H
I
S
G
Dog
Lupus familis
XP_535848
1288
147094
T194
R
T
A
Y
R
D
N
T
S
V
Y
H
I
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
G199
T
S
V
Y
H
I
S
G
K
K
K
T
F
K
D
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
A193
Y
H
R
K
K
N
I
A
A
E
R
K
E
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
T112
K
R
V
T
E
L
E
T
Q
K
E
K
S
N
E
Chicken
Gallus gallus
NP_989849
1274
145838
T215
M
M
K
P
K
G
Q
T
E
H
D
E
G
M
L
Frog
Xenopus laevis
P50532
1290
146971
G195
S
S
V
Y
H
I
S
G
K
K
A
T
F
K
D
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S193
R
T
A
G
K
D
N
S
S
A
Y
Y
I
N
T
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
G197
S
S
A
Y
Y
I
N
G
K
K
A
T
F
K
E
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
T354
A
Q
Q
R
K
S
S
T
P
V
K
P
I
L
A
Honey Bee
Apis mellifera
XP_396862
1282
148175
F193
V
D
L
D
H
N
R
F
L
I
L
Q
G
E
V
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
G207
S
S
S
Y
A
I
D
G
R
P
A
T
K
N
E
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
S215
R
T
A
H
K
D
N
S
S
S
Y
Y
L
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
E194
P
H
D
E
G
F
L
E
Y
L
E
D
I
I
G
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
S267
R
K
A
F
K
N
N
S
S
K
Y
Y
I
N
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
93.3
93.3
93.3
N.A.
0
0
N.A.
6.6
6.6
0
53.3
13.3
20
0
0
53.3
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
13.3
26.6
N.A.
20
13.3
13.3
80
20
33.3
13.3
26.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
48
0
6
0
0
6
6
6
18
0
0
6
6
% A
% Cys:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
6
6
6
0
36
6
0
0
0
6
6
0
6
12
% D
% Glu:
0
0
0
6
6
0
6
6
6
6
12
6
6
6
24
% E
% Phe:
0
0
0
6
0
6
0
6
0
0
0
0
18
0
0
% F
% Gly:
0
0
0
6
6
6
0
24
0
0
0
0
12
0
36
% G
% His:
0
12
0
6
18
0
0
0
0
6
0
24
0
0
0
% H
% Ile:
0
0
0
0
0
24
6
0
0
6
0
0
48
6
0
% I
% Lys:
6
6
6
6
36
0
0
0
18
30
12
12
6
18
6
% K
% Leu:
0
0
6
0
0
6
6
0
6
6
6
0
6
6
6
% L
% Met:
6
6
0
0
0
0
0
0
0
0
0
0
0
6
0
% M
% Asn:
0
0
0
0
0
18
48
0
0
0
0
0
0
24
0
% N
% Pro:
6
0
0
6
0
0
0
0
6
6
0
6
0
0
0
% P
% Gln:
0
6
6
0
0
0
6
0
6
0
0
6
0
0
0
% Q
% Arg:
42
6
6
6
24
0
6
0
6
0
6
0
0
0
0
% R
% Ser:
18
24
6
0
0
6
18
18
42
6
0
0
6
24
0
% S
% Thr:
6
36
0
6
0
0
0
42
0
0
0
24
0
0
6
% T
% Val:
6
0
18
0
0
0
0
0
0
30
0
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
0
42
6
0
0
0
6
0
42
18
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _